By John T. Shepherd (auth.), C. Tissa Kappagoda, Marc P. Kaufman (eds.)
On April 8-9, 1994, a symposium entitled keep an eye on of the Cardiovascular and respiration platforms in healthiness and ailment used to be held on the college of California Davis clinical middle in Sacramento. the aim of this symposium was once to honor the careers of Professors Hazel M. and John C. G. Coleridge. contributors during this symposium got here from during the global. Their attendance on the symposium was once an emblem of serious appreciate and affection for the honorees. The Professors Coleridge have made many vital contribu tions to the medical literature bearing on neural keep an eye on of the cardiovascular and respira tory platforms. additionally, they've got made amazing contributions to the lives of alternative scientists operating during this box of research. a few of us have identified them as mentors, counselors, neighbors, and supervisors; others have recognized them as co-investigators. most significantly, we all have recognized them as acquaintances. This e-book, which includes the lawsuits of the symposium, is devoted to Hazel and John Coleridge. C. T. Kappagoda M. P. Kaufman v ACKNOWLEDGMENTS we want to recognize the monetary help of the next organisations for making this symposium a truth: • Astra Merck team (Tarek Ackad, M. D. , Ph. D. ) • Boehringer Ingelheim prescribed drugs, Inc. (Ms. Kathryn B. Lucas and Mr. Allan Holloway) • Bristol-Myers Squibb (David L. Cram, Jr. , Pharm. D. ) • Marion/Merrrell Dow, Inc. (Mr. Brian Scheffield) • Merck and corporate (Mr. Johnathan Sakakibara) • Pfizer Laboratories (Mr.
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Extra resources for Control of the Cardiovascular and Respiratory Systems in Health and Disease
4). , 1987). Since the lower airway vasculature has a powerful sympathetic vasoconstrictor control (Matran, 1991), a decrease in sympathetic tone is probably part of the motor response. , 1991). If it is associated with increased interstitial liquid volume, then the resulting oedema will have a similar effect. Pulmonary C-fibre receptors and probably RARs also cause a nasal vasodilation with a tendency to airway blockage (Lung and Widdicombe, 1987). In asthma this could be harmful, since airflow will be diverted to the mouth with greater inhalation of potentially Pathophysiology of Bronchial Asthma ..
However experiments have to be done in man to test this concept and this is not yet possible in a definitive way. Inflating collapsed lung in man causes an unpleasant tearing sensation (Burger and Macklem, \968) and, since this stimulus acts on RARs but has little effect on C-fibre receptors, it seems likely that the former are responsible. 34 J. Widdicombe Thus both groups of receptors may cause unpleasant sensation. This is probably similar to many other tissues, such as the skin and skeletal muscle and various viscera, which have both C-fibre receptors and receptors with small myelinated fibres in the afferent nerves; both groups of receptors can cause an unpleasant sensation and the: quality of sensation depends upon the interaction of the two groups (Perl, 1984).
In Breathing: HeringBreuer Centenmy Symposium, ed. Porter, R. pp. 59-71, Churchill, London. S. (1972). Cardiovascular receptors. In Handbook of Sensory Phvsiology, VoL III/I ed. Neil, E. pp 1-45, Springer-Verleg, Berlin. S. (1977). Thoracic receptors connected with sensation. British Medical Bul/etin, 33, 169-174. Paintal. S. (1983). Lung and airway receptors. In Control of Respiration, ed. J. pp. 78-107, Croom Helm, London. S. (1986a). The visceral sensations - some basic mechanisms. Progress in Brain Research 67, 3-19.