By Claus-Michael Lehr
Over the last ten years a number of refined in vitro try platforms in line with epithelial telephone cultures were brought within the box of drug supply. those versions were discovered to be very beneficial in characterizing the permeability of substances throughout epithelial tissues, and in learning formulations or provider structures for greater drug supply and greater absorption. in comparison to in vivo trials on animals or people, cellphone tradition versions are quicker, less difficult and price potent, ethically helpful and, most significantly, they are often extra simply standardized and validated.
This e-book presents a pragmatic method of modern mobile culture-based in vitro options for drug shipping reviews at organic absorption boundaries. it's a useful resource of data for college students attending graduate classes in this topic and pharmaceutical scientists operating in or in academia.
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Extra resources for Cell Culture Models of Biological Barriers: In vitro Test Systems for Drug Absorption and Delivery
Sphingomyelin is a membrane phospholipid based on ceramide. Eukaryotic plasma membranes contain large amounts of cholesterol, with up to one molecule for every phospholipid molecule. Cholesterol molecules orient themselves in the bilayer with their hydroxyl groups close to the polar head groups of the phospholipid molecules. Their rigid, plate-like steroid rings interact with – and partly immobilize – those regions of the phospholipid hydrocarbon chain that are closest to the polar head groups, leaving the remainder of the chain flexible.
G. sphingomyelin). These glycosphingolipids have a general structure comprising a polar head group and two hydrophobic fattyacid chains. Glycolipids are distinguished from one another by their polar head group, which consists of one or more sugar residues. The most widely distributed glycolipids in the plasma membranes of eukaryotic cells are the neutral glycolipids whose polar head groups consist of 1–15 or more uncharged sugar residues. The varying lipid compositions of different membranes may well reflect the specific environments required for the optimal functioning of the respective membrane proteins.
Lapierre, L. A. (2000) The molecular structure of the tight junction. Adv. Drug Deliv. , 41, 255–264. , et al. (1998) Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J. , 142, 117–127. Matherly, L. , Schuetz, J. , Westion, E. and Goldman, I. D. (1989) A method for the synchronisation of cultured cells with aphidicolin: application to the large-scale synchronisation of L12210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase.