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Cardiac Regeneration using Stem Cells by Keiichi Fukuda, Shinsuke Yuasa

By Keiichi Fukuda, Shinsuke Yuasa

To in attaining cardiac regeneration utilizing pluripotent stem (iPS) cells, researchers needs to comprehend iPS mobile iteration tools, cardiomyocyte differentiation protocols, cardiomyocyte characterization equipment, and tissue engineering. This ebook offers the present prestige and destiny percentages in cardiac regeneration utilizing iPS cells. Written through best researchers who current new information in those fields, this ebook stories cardiac phone remedy for ischemic center ailment and explores in vitro iteration of efficacious platelets from iPS cells. It additionally discusses modeling arrhythmogenic center ailment with patient-specific brought about pluripotent stem cells.

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The purposes of this usage are the pathological analysis of disease and the development of an effective therapy. Currently, there are many methods for generating iPS cells. Many combinations of reprogramming factors, many vehicles to introduce transgenes, and many types of somatic cells that are introduced as reprogramming factors have been reported until today (Gonzalez et al. 2011). Although each of these methods has its own merits and demerits, it has so far been unclear as to which method is the best.

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26, 1276–1284. , and Yamanaka, S. 2008. Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 321, 699–702. , Kawamata, S. et al. 2011. Efficient generation of transgene-free human induced pluripotent stem cells iPSCs by temperature-sensitive Sendai virus vectors. Proc. Natl. Acad. Sci. USA. , Russ, H. , and Benvenisty, N. 2011. Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet Beta cells.

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