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Cardiac Mechano-Electric Coupling and Arrhythmias by Peter Kohl, Frederick Sachs, Michael R. Franz

By Peter Kohl, Frederick Sachs, Michael R. Franz

Cardiac Mechano-Electric suggestions and Arrhythmias offers a completely reviewed compendium written by way of best specialists within the box at the mechanism and effects of cardiac mechano-electrical coupling. Its insurance levels from stretch-activated ion channels to robotically triggered arrhythmias and mechanical interventions for middle rhythm correction. info is grouped into logical sections, from molecular mechanisms, to phone, tissue and full organ responses, all the way through to patient-based observations and perception rising from medical trials. the data supplied conscientiously highlights either consensus perception and present shortcomings in our realizing of cardiac mechano-electric coupling.

The booklet has been completely revised and increased considering that ebook of the 1st version in 2005, largely up to date to mirror fresh advancements within the box, and now deals a extra balanced view of mechano-electrical interactions within the center and develops a extra scientific concentration. Written with the complex clinical scholar and junior medical professional in brain, it is going to additionally supply attention-grabbing new perception for the proven doctor with an curiosity in cardiac arrhythmogenesis and center rhythm administration.

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Pflugers Arch 2001;442:64–72. 55. Cosens DJ, Manning A. Abnormal electroretinogram from a Drosophila mutant. Nature 1969;224:285–287. 56. Pedersen SF, Nilius B. Transient receptor potential channels in mechanosensing and cell volume regulation. Meth Enzymol 2007;428:183–207. 57. Beech DJ. TRPC1: store-operated channel and more. Pflugers Arch 2005;451:53–60. 58. Maroto R, Raso A, Wood TG, Kurosky A, Martinac B, Hamill OP. TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol 2005;7:179–185.

Microbiol Rev 1994;58:1–9. 13. Sachs F, Morris CE. Mechanosensitive ion channels in nonspecialized cells. In: Reviews of Physiology Biochemistry and Pharmacology. Springer, Berlin, 1998; Vol 33, pp. 1–77. 14. Kung C, Saimi Y, Martinac B. (1990) Mechanosensitive ion channels in microbes and the early evolutionary origin of solvent sensing. In: Current Topics in Membranes and Transport, (ed T Claudio). Academic Press, New York, pp. 9451–9455. 15. Kloda A, Martinac B. Structural and functional differences between two homologous mechanosensitive channels of Methanococcus jannaschii.

The membrane topology of the K2P subfamily is unique compared to other known potassium channels and is characterized by four trans-membrane domains (TM1–TM4) and two pore-forming domains (P1 and P2) (Fig. 3B). Both pore domains – P1 (located between M1 and M2) and P2 (located between M3 and M4) – contribute to a selectivity filter which forms a conduction pathway for K+. The functional channel assembles as a dimer of subunits. The stretch-activated TWIK (tandem of P domains in a weak inwardly rectifying K+ channel) -related subgroup (TREK) subgroup comprises three members: TREK1, TREK2 and TRAAK(49).

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