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Blockbuster Drugs: The Rise and Decine of the Pharmaceutical by Jie Jack Li

By Jie Jack Li

Blockbuster drugs-each of which generates greater than one billion funds a 12 months in revenue-have revolutionized the because the early Eighties, whilst revenues of Tagamet on my own reworked a minor Philadelphia-based company into the world's ninth-largest pharmaceutical corporation. In Blockbuster medicinal drugs, Jie Jack Li tells the attention-grabbing tales at the back of the invention and improvement of those hugely profitable medications, whereas additionally exploring the tumult the now faces because the "patent cliff" nears.

Having spent so much of his occupation in drug learn and improvement, Li brings an insider's eye to the narrative as he recounts the stories of discovery at the back of such medicines as Tagamet, Zantac, Claritin, Prilosec, Nexium, Serouquel, Plavix, and Ambien. As he discusses each one step forward, Li additionally exhibits that medical learn is full of human drama-serendipitous discoveries, unexpected insights, stressful confrontations. for example, the writer tells of James Black, who endured within the study that ended in Tagamet-and that might eventually win him a Nobel Prize-despite strain from best executives to pursue "more ecocnomic" paintings. The ebook indicates how learn in the back of Prilosec mixed creativity, foreign cooperation, and luck-the turning aspect being an opportunity come across of yankee and Swedish scientists at a convention in Uppsala. There also are stories of brilliant rewards—George Rieveschl, the chemist who invented Benadryl, made a fortune on royalties-and of unjust cakes. ultimately, Li exhibits that for the world's biggest prescription drug brands, contemporary years were harrowing, as many renowned medicinal drugs have come off patent within the U.S. industry, that means enormous quantities of billions of bucks in misplaced profit.

Anyone who enjoys stories of clinical discovery, or is serious about the background in the back of the prescriptions they take, or wishes a revealing inside of examine the pharmaceutical will locate this publication worth interpreting.

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Extra resources for Blockbuster Drugs: The Rise and Decine of the Pharmaceutical Industry

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In 1966, John Emmett (who came to SK&F Labs Ltd. in 1965) synthesized 4-methyl-histamine, which stimulated acid secretion. That was exactly the opposite of what they wanted to do, because 4-methyl-histamine was an H2 agonist, not an antagonist. 14 The discovery was scientifically monumental, but much, much more was needed to find a bona fide drug to suppress gastric acid secretion. Understandably, there was enormous pressure within the company to abandon this approach in favor of the approach being carried out in Philadelphia.

But as the project’s complexity became manifest, the chemistry team grew to three, Durant, C. 6), with Ganellin, a brilliant medicinal chemist, as the team leader. 12 It was fortunate that Black and Duncan invited him back a bit later. Otherwise, the Tagamet breakthrough might have been crucially delayed or even quashed. The challenge was tremendous: The chemistry was unusual in that there was no known lead molecule (except histamine as the endogenous ligand) with the required properties to build upon.

The Welwyn chemists at the time turned their attention to non-thiourea analogues of metiamide. One of the thiourea replacements was cyanoguanidine, which has an amino-nitrile in place of the sulfur atom. The compound, synthesized by Graham Durant in 1972, was cimetidine. Cimetidine, with seemingly minor changes in the structure of the side chain in comparison to metiamide, was tenfold more potent than burimamide in vitro and had twice the activity of metiamide in vivo in inhibiting gastric acid secretion.

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