By P. Alexander
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Additional info for Bioreduction in the Activation of Drugs. Proceedings of the Second Biochemical Pharmacology Symposium, Oxford, UK, 25–26 July 1985
H o l d e m a n , Cancer Res. 3 5 , 3418 (1975). 18. V . C. Aries, J. S. Crowther, B . S. Drasar, M. J. Hill and R. E . O . Williams, Gut 10, 334 (1969). 19. B . S. Drasar, J. S. Crowther, P. Godard, G. Hawksworth, M. J. Hill, S. Peach, R. E . O . Williams and A . Renwick, Proc. Nutr. Soc. 3 2 , 49 (1973). 20. B . G. Reddy, L. R. Pohl and G. Krishna, Biochem. Pharmac. 2 5 , 1119 (1976). 21. J. C. Mirsalis, T. E . H a m m , J. M. Sherrill and B . E . Butterworth, Nature, Lond. 295, 322 (1982). 22.
00 © 1986 Pergamon Press Ltd. Biochemical Pharmacology, Vol. 35, No. 1, pp. 33-36, 1986. Printed in Great Britain. THE M E T A B O L I C ACTIVATION OF R O N I D A Z O L E [(l-METHYL-5-NITROIMIDAZOLE-2-YL)-METHYL C A R B A M A T E ] TO REACTIVE METABOLITES B Y M A M M A L I A N , CECAL B A C T E R I A L A N D T. FOETUS ENZYMES GERALD T. MIWA, REGINA W A N G , R A U L A L V A R O , JOHN S. WALSH and ANTHONY Y. H. Lu Department of Animal Drug Metabolism, Merck Sharp and D o h m e Research Laboratories, Rahway, NJ 07065, U .
29 Reduction by the gut microflora of animals and man closer animal model of a human gut flora by an alteration in laboratory animals diet (see below). Differences in distribution of the gut flora between animals and man As well as differences in the rates of microbial reductive metabolism between laboratory animals and man there are marked dissimilarities in the distribution of bacteria within the gastrointestinal tracts of different animal species, which have potentially profound consequences for drug metabolism.