By R. Glaser
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Additional resources for Biophysics
Capillaries Capillaries have a thin wall of endothelium and a variable basement membrane. Isolated cells called pericytes are scattered along the capillary inside the basement membrane. These cells are undifferentiated and can become many different cells including smooth muscle. The continuous capillary has no interruptions or pores in the endothelium. Tight junctions are present between cells. Continuous capillaries are found in muscle or lung. The fenestrated capillary has small pores scattered throughout the endothelial cells of the vessel wall.
Immune cells in the lamina propria include T and B cells, macrophages, dendritic and mast cells. T lymphocytes in the lamina propria primarily express CD4 surface proteins and are recognized as helper cells which promote proliferation, development and immune function of other cells. B cells in the lamina propria are mostly plasma cells which produce antibodies. Dendritic cells act as antigen-presenting cells while macrophages in the lamina propria are primarily phagocytic. the cell. Foreign materials on the epithelial surface, such as bacteria, are pinocytosed by the M cells, and antigens are presented to the underlying cells.
The tingible body macrophages remove the dead cells. T cells which survive the selection process then migrate into the medulla of the thymus as naive T cells. From the medulla, the T cells subsequently pass to secondary lymphoid organs such as lymph nodes and the spleen where the cells will be exposed to antigens. Medulla of the Thymus Medullary epithelial reticular cells, which are somewhat larger than their cortical counterparts, form the framework in the medulla of the thymus. The medulla is lighter staining than the cortex, as fewer small lymphocytes and macrophages fill the space of the framework.