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Animal models in cardiovascular research by David R. Gross DVM, PhD (auth.)

By David R. Gross DVM, PhD (auth.)

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E. morphine tolerance develops 36 Cheek-pouch preparation, no anesthesia described Topical application Dilates arterioles, decreased potency and increases tolerance when chronically pretreated. 25 g/ml, 1 g/ml and 100 g/ml 85% decrease in heart rate at lowest dose, 79% decrease at 1 g/ml and only 63% decrease at 100 g/ml 37 Isolated papillary muscle preparation, from freshly stunned animals Dose response from 1-10 fl Moill Mol/l No effect on action potential parameters or force of contraction. 1:7 Pigs Halothane anesthesia, open ehest, chest, total and right heart by-pass preparations 10 mg/kg, IV No change in stroke volume, during normoxia no change in myocardial oxygen consumption but during hypoxia myocardial oxygen consumption decreased.

Lglkg each Progressive decrease in heart rate, decrease in mean aortic pressure, effects blocked by atropine. The second dose reduced the decline in ventricular fibrillation threshold caused by LAD occlusion. 5:1 Dogs Pentobarbital anesthetized (30 Ilglkg Ilg/kg IV) n=12 lOOllglkg lOOllg/kg Increased R -R interval, atrial HIS interval, paced atrial-HIS interval, AV nodal effective refractory period, AV nodel functional refractory period and retrograde ventricular effective refractory period. No change in HIS-ventricle interval.

Onset of action within a few minutes following injection. 1-2 mg/kg, mglkg, SC Very young, aged and debilitated dogs seem to be more sensitive to respiratory depression. 2 Conscious, previously instrumented, intact instrurnented, 2 mglkg, mg/kg, IV Initial transient decrease in coronary resistance, initial increase in heart rate and in left ventricular dP/dt and dP/dt/P, decrease in left ventricular dP/dtIP, end-diastolic diameter and left ventricular end-systolic size. These responses followed by an increase in coronary resistance lasting 5-30 min.

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