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Angiogenesis: From the Molecular to Integrative Pharmacology by Michael E. Maragoudakis (auth.), Michael E. Maragoudakis

By Michael E. Maragoudakis (auth.), Michael E. Maragoudakis (eds.)

Proceedings of the fifth Biannual overseas assembly on Angiogenesis: From the Molecular to Integrative Pharmacology, held July 1-7, 1999, in Crete, Greece.
Angiogenesis, as a drastically advanced organic strategy, has challenged researchers from all easy clinical disciplines, together with pharmacology, biochemistry, body structure, embryology and anatomy. the importance of this phenomenon for the learn of sickness states has additionally clinicians from a few professional fields. This multidisciplinary paintings displays the expansion of expertise of recommendations equivalent to angiogenesis dependent treatment, the large healing and advertisement power of which has attracted significant examine and funding lately. This quantity, which goals to bridge the distance among simple and medical technique and figuring out, provides the main up to date advancements during this field.

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Among them, VEGF appears to play an important role in tumor neovascularization (Martiny and Manne, 1995). , 1994), can inhibit tumour growth in different 23 experimental models. , 1996). At variance with VEGF, FGF2 lacks a hydrophobic signal sequence needed to enter the secretory pathway and is usually poorly secreted by producing cells. , 1994). , 1991). These data suggest that FGF2 release may occur in vivo and may influence solid tumour growth and neovascularization by autocrine and paracrine modes of action.

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And D'Amore P. A. ,1997, Vascular development: cellular and molecular regulation. FASEB J. 11: 365-373. 27. Benjamin L. , Hemo I. and Keshet E. ,1998, A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 125: 1591-1598. , Yee E. and Harlan J. M. ,1996, Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, AI. J. Bioi. Chern. 271: 27201-4.

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