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Affinity Capillary Electrophoresis in Pharmaceutics and by Reinhard Neubert (Editor), Hans-Hermann Ruttinger (Editor)

By Reinhard Neubert (Editor), Hans-Hermann Ruttinger (Editor)

This quantity offers breakthroughs and strategies in affinity capillary electrophoresis to degree and make sure the physicochemical and thermodynamic parameters of drug compounds. It discusses recommendations to discover and represent interactions to facilitate advancements in managed drug supply and concentrating on.

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Example text

7a). The depletion peak moves with the velocity of the substrate, and its area corresponds to the bound substrate. As demonstrated in Fig. 7b, the Fig. 7 Same conditions as in Fig. 5 mm. Theory of Affinity Electrophoresis 41 complex and the ligand cause a positive peak. Calculated in concentration units, the positive complex peak embodies the same area as the negative peak of the substrate depletion. To get the concentration of free substrate, the negative peak area must be calibrated against the substrate concentration.

The length of that zone, is proportional to the solute quantity in the sample. Therefore, in CITP a characteristic separation plot contains steps of different length. And CITP is favorably utilized in the analysis of low-molecular-weight ionic species. A difficulty often arises with finding suitable buffer systems that provide leading and terminating ions and also form the appropriate buffer pH. One of the advantages is that the capillary can be loaded with sample up to 30–50% of its length, enabling the analysis of very dilute samples.

3. 4. 5. 6. KA Connors. Binding Constants. The measurement of molecular complex stability. Wiley, New York, 1987. RHH Neubert, MA Schwarz, Y Mrestani, M Pla¨tzer, K Raith. Affinity capillary electrophoresis in pharmaceutics. Pharm Res 16:1663–1673, 1999. RM Guijt-van Duijn, J Frank, GWK van Dedem, E Baltussen. Recent advances in affinity capillary electrophoresis. Electrophoresis 21:3905–3918, 2000. NHH Heegard, RT Kennedy. Identification, quantitation and characterization of biomolecules by capillary electrophoretic analysis of binding interactions.

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