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2011-2012 Basic and Clinical Science Course, Section 1: by Eric P. Purdy, MD

By Eric P. Purdy, MD

Covers systemic health conditions probably to impact ophthalmic sufferers, comparable to infectious, metabolic, neurologic and cardiovascular illnesses; melanoma; and rheumatic and endocrine problems. incorporates a dialogue of preventive medication and scientific emergencies, in addition to geriatrics and records. Ophthalmic issues are highlighted all through. comprises a number of up-to-date references and tables directory the names, symptoms and uncomfortable side effects of antibiotic, antihypertensive and anticancer medicines. lately revised 2010 2011.

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Proteasesparing regimens such as abacavir/AZT/3TC (Trizivir) and drug combinations that include efavirenz appear to be as effective as regimens that contain protease inhibitors. HAART has been shown to result in a dramatic reduction of the HIV viral load. increased CD4 cell counts. delay of disease progression. reduction in the number of opportunistic infections. decreased number of hospitalizations. and prolonged survival. Some statistics show up to an 82% decline in the number of opportunistic infections in patients on HAART.

However, didanosine has been associated with peripheral retinal toxicity. Lamivudine is available as a combination drug with zidovudine (Combivir). Abacavir (Ziagen) was the first clinically available guanosine analogue reverse transcriptase inhibitor. Trizivir is a combination drug containing abacavir, lamivudine, and zidovudine. Tenofovir (PMPA; Viread) is a nucleotide reverse transcriptase inhibitor (NRTI) that allows 34 • Update on General Medicine for once-daily dosing and has been well tolerated in clinical trials to date.

Farci P. Roskams T. Chessa L, et al. Long-term benefit ofinterferon alpha therapy of chronic hepatitis D: regression of advanced hepatic fibrosis. Gastroenterology. 2004;126(7}:1740-1749. Fried MW, Hadziyannis SJ. Treatment of chronic hepatitis C infection with peginterferons plus ribavirin. Semin Liver Dis. 2004;24(suppI2):47-54. Tang YW, Li H. Roberto A, Warner D, Yen-Lieberman B. Detection of hepatitis C virus by a user-developed reverse transcriptase-PCR and use of amplification products for subsequent genotyping.

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